J.Jpn. Surg. Soc.. 58(2): 294-312, 1957
HISTOCHEMICAL STUDIES ON PHOSPHATASE OF MAMMARY CARCINOMA AND DYSPLASIA
PARTⅡ: CLINICAL STUDY ON PHOSPHATASE
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Surgical Department, Kanto Teishin Hospital,, Tokyo (Director: Dr. Shunji ISHIYAMA) Susumu ISEKI |
The results were summarized as follows:
1) The alkaline phosphatase activity was very prominent in all 40 cases of mammary dysplasia, not only in parenchyma but also in their stroma. The activity of alkaline phosphatase in adenosis was particularly stronger than that of mazoplasia. These histochemical findings seemed to be functional and essential differences between both types of mammary dysplasia.
The acid phosphatase activity in these condtions was very poor as compared with their alkaline phosphatase, and it was demonstrated in 2 of 40 cases (5%) of the mammary dysplasia in their alveolar and ductal epithelium.
2) Alkaline phosphatase in the fibroadenoma was demonstrated as abundant as that of adenosis.
3) There were no significant alkaline phosphatase activity in cancer cells of the primary and metastatic mammary carcinomas. However in 2 of 11 cases of mammary carcinoma alkaline phosphatase activity was demonstrated in only limited areas. And these were cases of scirrhous adenocarcinoma and comedo carcinoma.
On the contrary, there were significant acid phosphatase activity in almost all cases of mammary carcinomas. These histochemical alterations were essential differences between mammary dysplasia and carcinoma.
4) Both alkaline and acid phosphatase activities were markedly demonstrated in cases of the mammary dysplasia which were combined with the mammary carcinoma.
5) The alkaline phosphatase markedly decreased in the mammary dysplasia when it had been treated with androgen. On the contrary simple progesterone or combined ;progesterone with estrogen produced no significant changes upon the enzyme activity.
(author's abstract)
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