J.Jpn. Surg. Soc.. 58(2): 248-257, 1957

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STUDIES ON THE SPECIFITY OF BRAIN METABOLISM

Embden-Meyerhof schema is now generally believed to be the pathway of glucose break down in the brain, but the low turn over rate of p³² in the brain cannot be fully explained based on this theory.
Citrate does not stimulate the O₂-uptake of a brain slice and its homogenate. And both fumarate and malate also show similar tendency, but some times these stimulate the O₂-uptake slightly. Succinate and Ketoglutamic acid, which stimulate the O₂-uptake, do not accelerate the oxidation of pyruvate as “Sparker”.
Malonate gets no inhibition effect on the oxidation of glucose and pyruvate in the brain.
These data throw doubt on the validity of Krebs TCA cycle hypothesis in the brain. The pattern of brain metabolism may be specific.
(author's abstract）

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