J.Jpn. Surg. Soc.. 58(1): 188-200, 1957
HISTOCHEMICAL STUDIES ON PHOSPHATASE OF MAMMARY CARCINOMA AND DYSPLASIA
PARTⅠ: EXPERIMENTAL STUDY ON PHOSPHATASE OF NORMAL BREAST TISSUES
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Surgical Depertment, Kanto Teishin Hospital,, Tokyo (Director: Dr. Shunji ISHIYAMA) Susumu ISEKI |
The results were summarized as follows :
1) The alkaline and acid phosphatase activity in the mammary tissue changed closely relating with physiological developments of the breast. And the all aline phosphatase activity intensively increased in the early stage of pregnancy, while acid phosphatase activity intensively increased from the end stage of pregnancy to the early stage of lactation.
2) As regards the influences of castration upon the alkaline phosphatase activity, it was evident that the enzymentirely disappeared 15 days after castration when the animal was virgin and when it was in the lactation or postlactation stage. The phosphatase inactivating effect of castration in pregnant animals was less than the others, but there occurred no entire disappearance at that time.
3) Among various sex hormones administered to the castrated virgin rabbits, the estrogen potentiated alkaline phosphatase activity in the luminal pithelium and the myoepithelium of mammary tissues, the progesteron potentiated that of myoepithelium but not produced any influences on the glandular epithelium. And the androgen did not show any enzyme activating effect. In the combined administrations it was resulted that, estrogen and progesterone were indifferent, while estrogen and androgen were antagonistic in their alkaline phosphatase activating effects.
No sex hormone influenced the acid phosphatase activity in the breast tissues.
4) At the same time the histological changes in mammary tissues of the castrated virgin rabbits treated with sex hormones were also observed. Estrogen made development of the ductal systems, progesterone made lobular-formation, while androgen did not produce these changes in the same mammary epithelia.
(author's abstract)
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