J.Jpn. Surg. Soc.. 58(1): 161-187, 1957

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STUDIES ON IRON METABOLISUM IN GASTRIC DISEASE

With normal 11 male and 10 female subjects as control changes in the serum iron contents of pre-and post-operative patients of 29 cases of gastric and duodenal ulcers and 46 cases of gastric cancer were studied. Iron contents of the liver and lymph glands were also measured in 95 clinical cases. Iron absorption of 7 normal subjects, 8 cases of gastric cancer and 35 experimental animals were observed and the following results were obtained.
1. Remarkable differences were seen in the serum iron content of normal subjects, ulcer cases and gastric cancer cases.
Patients with cancer gave values of only 46.5% of normal showing a remarkable reduction.
2. Compared to the control and ulcer cases the liver iron content of gas!ric cancer was remarkably reduced in the fraction of non-hemin iron but in the differential count remarkable reduction was seen in P II and increase in the fraction of P I and P III.
3. Removal of cancer lesion causes an increase of the serum iron. Whereas cancer-resected groups shows a rapid increase after the 7th hospitalized day the unremoved cases show a reduction of serum iron after the 7th day. From this observation it can be said that cancer resection plays a large role in iron metabolisum.
4. The iron content of lymph glands with cancer metastasis when compared with those of hypertrophi ed lymph glands of stomach and duodenal ulcers were reduced.
5. The absorption of iron when compared to normal subjects showed a 31% reduction in cancer. This confirms the fact that there is a greater disturbance of iron absorption by the mucous membrane in gastric cancer than the reduction of iron content of the mucous membrane in the stomach and duodenum.
(auther's abstract)

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