J.Jpn. Surg. Soc.. 58(1): 148-160, 1957

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AN EVALUATION OF ANTIBIOTIC TREATMENT OF THE WOUND HEALING OF EXPERIMENLAL INTESTINAL ANASTOMOSIS

End-to-end anastomosis of the large bowels of the dog was performed in 8 control dogs and other dogs received intraperitoneal penicillin at the operation, postoperative intramuscular penicillin, postoperative intramuscular penicillin with streptomycin or intravenous or oral tetracycline. The animals were reoperated on the 7th, 14th and 28th postoperative days and their healing processes of anastomosis were studied.
Intestinal adhesions and inflammatory reactions were observed in almost all control dogs. We found histopathologically inflammatory cell infiltrations, tissue necrosis, hemorrhage and bacterial invasions in their wound areas. One of them died of perforative peritonitis after 48 hours.
Single intraperitoneal penicillin ast the operation was not very effective for the control of wound infection of the anastomosis. Daily postoperative intramuscular penicillin injection inhibited the intestinal adhesion and the bacterial invasion into the anastomosis wound. Intravenous chlortetracycline with oral chlortetracycline on succesive days had almost the same effect.
Combined use of the intramuscular penicillin and streptomycin was very successful to control the intestinal adhesion and bacterial invasion.
It was concluded that combined use of penicillin and streptomycin was the most effective to repress the infection in the abdominal wall and intraperitoneal cavity and it was advisable to use antibiotics intraperitoneally at the operation and succesively after the operation intramuscularly.
(author's abstract)

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