J.Jpn. Surg. Soc.. 57(10): 1698-1712, 1957

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AMOUNT OF VITAMIN C NEEDED BEFORE AND AFTER OPERATION

In order to quantitate the amount of vitamin C needed before and after operation on 88 patients and 13 controls were examined for vitamin C concentration in the blood and excreted in the urine. Tests were done 2 weeks― over 1 month after operation using the Wychgram (Roe) method. The results are as follows:
1. Not always there is a correlation between the concentration in blood and urine. When vitamin C level reaches the point of saturation in urine it has reached saturati on in blood but on the other hand when it reaches saturation in blood not necessarily it is so in the urine.
2. The average amount necessary to concentrate vitamin C to the point of saturation is 320 mg in normals, 1000 mg in breast cancer and gastric ulcer, 1500 mg for pulmonary tuberclosis, 2100 mg for pulmonary gangrene and 2250mg for lung cancer.
3. The average amount of vitamin C consumption per day is 30 mg for normals, gastric ulcer 42.5 mg, breast cancer 45.8 mg pulmonary gangrene 57 mg, pulmonary tuber closis 67.5 mg and lung cancer 69.5 mg. The amount of vitamin C consumption has no relation to the spread of the disease but more so to the progress of exsudation and speed of the erythrocyte sedimentation rate.
4. The method used postoperatively to keep vitamin C level at saturation is as follows :
In cases of thoracoplasty and gastric cancer 300 mg of vitamin C was given per day 2 consecutive days after operation, 200 mg per day for 5 days and 100 mg per day thereafter. For gastrectomy and breast resection in breast cancer 200 mg per day for 3 days and 100 mg per day thereafter.
(author's abstract)

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