J.Jpn. Surg. Soc.. 57(7): 1214-1224, 1956
STUDIES ON MIXED INFECTIONS
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Department of Surgery, Tokyo Teishin Hospital (Director: Dr. H. Nakatani) Modo CHIN |
These patients were given antibiotics (penicillin, colimycin (colistin) and aureomycin) before operation and their course was studied.
After appendectomy the exsudate in the appendix was cultured separatly for aerobic and anaerobic bacteria.
Different combinations of bacteria were made and injected into the knee joint of rabbits.
Results were as follows :
1) In acute appendicitis the bacteria found wer orgnisms commonly found in the intestines and showed a state of a mixed infection. When using a wide range antibacterial drug such as aureomycin or even in the smaller range penicillin or colimycin (colistin) it not only enlightens the appendicitis simplex clinically but definitely limits the different kinds of bacteria and decreases the number of living bacteria.
Therefore, we can assume that in a mixed infection there is a relation in symbiosis.
2) In appendicitis destructiva along with passage disturbance it resembles an abscess. Therefore, it is difficult to rely on antibiotics alone.
In other words there is a limit to conservative treatment.
3) In the knee joint of rabbits when a single strain of bacteria is injected there is little change or even if there is an inflammation, it is very mild, but, if a combination of strains is administered there is a definite inflammation and many bacteria are found.
4) Experimentally such an antibiotic which would effect one strain but not another, was mixed with the combined strain of bacteria and injected into the knee joint of rabbits. In this case the inflammation was milder and recovery was more rapid and less colonies were found in comparision to controls.
5) Clinically, in experimental animals it may be assumed that in cases of mixed infections the virulence of the bacteria seems to multiply rather than plain summation.
(author's abstract)
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