J.Jpn. Surg. Soc.. 57(7): 1164-1176, 1956
AN EXPERIMENTAL INVESTIGATION OF THE DEVELOPMENT AND PROGRESS OF APPENDICITIS, ESPECIALLY ALLERGIC APPENDICITIS DUE TO EXOTOXIN WELCHI.
|
The First Surgical Clinic, Faculty of Medicine, Kyushu University (Director: Prof. H. Miyake) Yashuyuki KAMADA |
2) Allergic inflammation due to exotoxin Welchi developed faster with greater severity than normergic inflammation, the former reaching the acme in some 12 hours and the latter in some 24 hours.
3) In allergic appendicitis there occurred in the interstitial connective tissue, simultaneously with inflammation of the lymph follicles, a sudden disturbance of the local circulation exudation of body fluids, infiltration by leucocytes, monocytes, histiocytes, epitheloid cells, and plasma cells, thickening and degenerative swelling of connective tissue, and reticulation of blood capillaries.
In normergic inflammation the only notable symptom was inflammation of the lymph follicles.
4) As may be presumed from the preceding statement, inflammation spread from the interstitial to the surrounding tissue in allergic inflammation, and mainly from the lymph follicles to the surrounding tissue in normergic inflammation.
5) The experimental allergic appendicitis described above bore a close histological resemblance to relapsing human appendicitis, macrospical observation and experimental examination showed tha t the appendix vermiformis was bent and thickened in the former condition as in the latter.
6) The results described above show that Welch's bacterium, more particulary its exotoxin, is to be taken as a non-negligible agent in considering the cause of acute appendicitis and recurrent allergic appendicitis.
(author's abstract)
To read the PDF file you will need Adobe Reader installed on your computer.