J.Jpn. Surg. Soc.. 57(3): 423-429, 1956

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PYRUVIC ACID METABOLISM ON THE EPILEPTICS
Part3. BLOOD PYRUVIC ACID AND LACTIC ACID CONCENTRATION LEVELS DURING EPILEPTIC CONVULSION

The aerobic pathway of pyruvic acid transformation on the epileptics was formerly reported by the author. In this article, anaerobic glycolysis of the epileptics was studied by the estimation of blood pyruvic and lactic acid concentration levels throughout idiopathic and induced metrazol convulsions. In the idiopathic convulsion, high concentration of blood pyruvic acid periodically observed near the attack once decreased just before the fit. Prominent increase of pyruvic acid was observed after convulsions. Thus the author employed metrazol convulsion on the epileptics to prove this mechanism and obtained the following results :
1) In the pre-convulsive stadium when there was no clinical signs visible, blood pyruvic acid decreased and, on the other hand, lactic acid increased.
2) When intravenously administered metrazol could not induce convulsion above described sign as 1) was not observed.
3) During the convulsion, increasing tendency of pyruvic acid became prominent, while lactic acid showed no particular changes in this stadium.
4) After the convulsion, both substances showed prominent increase, and the highest peak of lactic acid initated than that of pyruvic acid.
5) The influence of convulsion was continued for 45-60 min. on blood pyruvic acid and lactic acid concentration levels．
6) In the epileptic attack, until the beginning of tonic convulsion the glycolysis has the tendency of anerob and after that it transfered to aerobic glycolysis．
(author's abstract)

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