J.Jpn. Surg. Soc.. 57(3): 417-422, 1956

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PYRUVIC ACID METABOLISM ON THE EPILEPTICS
Part2. THE EFFECTS OF THIAMINE AND COCARBOXYLASE ON THE BLOOD PYRUVIC ACID LEVELS OF THE EPILEPTICS

In the former report, the author found the extraordinary increase of blood pyruvic acid concentration level and its variation in the convulsive period excluding the direct influence of fit itself. The fact leads the author to investigate, furthermore, about the detail of metabolic relations of this substance on the patient periodically excluding the epileptic attack itself. In this experiment the author administered thiamine and cocarboxylase intravenously to the epileptics and measured the blood concentration level of this pyruvic acid with 10-15 min. interval. Dosis of the administered thiamine and cocarboxylase was 1 mg-100 mg and 5 mg-40 mg.
Obtained results are as follows :
1) The effect of thiamine on blood pyruvic acid of the epileptics continued within 90 min. And when the control value was high, the effect of thiaminecould not induce the level within normal.
2) When the dosis of administered thiamine was increased to 20 mg the decrease of blood pyruvic acid was observed corresponding with applien dosis of thiamine. But, when the dosis of thiamine was above 20 mg, it showed no significant results comparing with the data being injected 20 mg.
3) Cocarboxylase could decrease the blood level of pyruvic acid more easily than thiamine. It could make the pyruvic acid level in normal value in long duration, even though the control value might be high.
4) Cocarboxylase acts earlier than thiamine. When it was given in same dosis as vitamin B1, the decrease of blood pyruvic acid level showed more prominent effect in the cocarboxylase case than that of thiamine.
5) The effect of cocarboxylase upon normal adult showed only slight decrease of blood pyruvic acid level without any harmful side effect.
6) The increasing mechanism of blood pyruvic acid on the epileptics is considered to be the influence of the periodical disturbance of thiamine phosphorilation, which was related with the velocity of the ATP cycle.
(author's abstract)

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