J.Jpn. Surg. Soc.. 57(3): 309-329, 1956

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EXPERIMENTAL AND CLINICAL STUDY OF THE INTRA-INTESTINAL SUPPLY OF OXYGEN

It is undeniably very important to pay attention to anoxia of the liver in treatment of various kinds of surgical diseases. Thereupon, we devised the method of intra-portal vein injection of oxygen-saturated blood and conducted a number of clinical and experimental studies. Following this, we thought of infusing oxygen into the intestines,
Clinically and experimentally, we infused oxygen into the intestines of grown-up dogs and healthy rabbits, and observed carefully ileus (intestinal obstruction) and rise and fall of the amount of oxygen in portal vein blood at the time of venesection.
Absorption of oxygen in the small and large intestines is rapid. The increases of intestinal gas at the time of ileus is chiefly due to swallowing of air. Oxygen is also well absorbed in the intestines at the time of ileus. is Chiefly due to swallowing of air. Oxygen is also well absorbed in the intestines at the time of ileus.
The amount of oxygen in portal vein blood increases within a short time due to the intra-intestinal infusion of oxygen, and the similar phenomena were seen at the time of ileus. Moreover, the effectiveness was even observed for 48 hours after ileus was removed.
The infusion also brought about the improvement of liver functions and good influence upon the amount of blood flow in the liver, of circulating blood, and of oxygen consumption in the internal organs.
As to the pathological changes of the liver at the time of removal of ileus, the sign of recovery was recognized on the 4th day after the removal and the sign was particularly recognized in severe ileus in comparison with slight ileus.
We found peculiar changes in the amount of oxygen in portal vein blood within a short time by portal vein venesection (we took blood through vinyl tube inserted from the mesenterial vein into the portal vein), and observed extremely favorable influence and effectiveness by means of the intra-intestinal infusion of oxygen after re-bleeding in the portal vein.
The prolongation of the portal vein circulation time caused by portal vein venesection was shortened by the intra-intestinal infusion of oxygen, but the prolongation of the portal vein circulation time caused by portal vein venesection after splenectomy was not shortened by the intra-intestinal infusion of oxygen.
In short, bleeding in the portal veins brings about effects especially to the liver, and as the treatment of this it is considered that the intra-intestinal infusion of oxygen together with the injection of oxygen blood into the portal vein will bring about remarkable results.
(author's abstract)

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