J.Jpn. Surg. Soc.. 57(2): 198-219, 1956

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EXPERIMENTAL STUDIES ON THE EFFET OF CHEMOTHERAPY AGAINST ACUTE ILEUS

Experimental ileus, acute simple in some cases and of the nature of strangulation in others, was formed in cats and rabbits for observation of the duration of subsequent life, the postoperative general conditions, the consequent changes in the intestinal flora, the bacterial permeation through the strangulated intestinal wall and the local condition of the abdominal region. The findings were compared with those obtained after the use of certain therapeutic chemical agents. The following results were obtained.
1) Given after the formation of ileus Sulfadiazine, Penicillin, Streptomycin and Aureomycin-particularly the last-named agent-prolonged the duration of postoperative life in the experimental animals.
2) The intestinal flora was remarkably more increased in these animals with ileus than in controls and went on increasing with the duration of the condition.
3) Aureomycin, given in ileus, diminished the intestinal flora.
4) Penicillin and Streptomycin, given in strangulation ileus, retarded the necrosis of the strangulated segment of the intestinal wall and prevented the bacterial permeation of that part of the intestinal wall for some time (for 6 hours or so).
5) Some few intestinal bacteria were found to have made their way through the strangulated segment of the intestine soon-2 hours-after the strangulalion when that part of the wall gaven no macroscopical sign of necrosis.
6) As examined when the ileus was relieved and on auotpsy, the adhesion resulting and the peritonitis developed were less advanced in animals given therapeutic chemical agents than in controls.
7) The experiment made it presumable that the intestinal flora might be working as a powerful factor in bringing about death in ileus.
8) Chemotherapy is recommendable as a supplementary measure in the treatment of ileus, but the cause of death in the condition is exceedingly manifold, implying various conditions not amenable to chemotherapy. It therefore appears that no radical treatment of ileus would be possible in many cases without recourse to a surgical measure supplemented by chemical and other conventional auxiliary therapies.
(author's abstract)

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