J.Jpn. Surg. Soc.. 57(2): 175-197, 1956
EXPERIMENTAL STUDIES ON PROTECTIVE ACTION IN HEMORRHAGIC SHOCK BY PHARMACOLOGICAL HIBERNATION
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First Surgical Department, Tokyo University School of Medicine (Director: Prof. Kentaro SHIMIZU) Masahito YAMADA |
There was studied producing hemorrhagic shock in two general groups: (a) Those in which, to maintain at predetermined levels, enough blood was withdrawn by connecting the femoral artery to a receptacle, and (b) those in which a fixed blood volume was withdrawn, regardless of the changes induced in arterial pressure.
In the former group, pharmacological hibernation pretreated dogs showed significantly greater survival rates and less total bleed out volumes than control in the group.
In the latter group, in spite of being induced lower hypotension, hibernated dogs survived in greater rates than controls in the group.
Between hibernated and control groups, there was no definite differences in oxygen consumption, but cerebral oxygen consumption was found to be remarkably reduced by being induced pharmacological hibernation.
In addition to reduction of bleeding volume, marked reduction of cerebral oxygen consumption should be considered to be one of factors of the protective action in hemor rhagic shock. In the respiration, pulse rate, rectal temperature, blood specific gravity, hematocrit, serum potassium and nonprotein nitrogen of blood, there were some differences between two groups.
These differences might be considered to be not so important factors for the prevention of hemorrhagic shock.
The prevention of hemorrhagic shock might be not influenced by giving ACTH in the hibernated group. (author's abstract)
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