J.Jpn. Surg. Soc.. 57(1): 109-120, 1956

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THE RENAL CIRCULATION IN SHOCK AND THE EFFECTS OF AUTONOMIC BLOCKADE (AN EXPERIMENTAL STUDY USING INK-INFUSION METHOD)

The renal circulation during shock and the effects of autonomic blokade and adrenal insufficiency were studied from microscopic preparations of the kidney after infusion of lndia ink through the renal artery under the following conditions:
(1) Control, with and without eIetric shock only.
(2) Bilateral splanchnicectomy, with and without eletric shock.
(3) Venoclysis of hexamethonium bromide, with and without eletric shock.
(4) Stripping of the adventitia of bilateral renal vessels, with and without eletric shock.
(5) Bilateral adrenalectomy, with and without eletric shock.
The shock was produced by passing an electric current of 8,000 to 10,000 joules through both thighs of rabbits.
The following results were obtained :
(1) The renal blood flow was diverted to the juxta-medullary glomeruli after the passage of shock-dosis of eIectricity in untreated rabbits, and the diversion became more marked with time and with decrease of the renal blood flow.
(2) The diversion of the renal blood flow to the juxta-medullary glomeruli is due to active constriction of the renal cortical vessels through nervous controI and the renaI cortical ischemia obviously influences the general circulation.
(3) Extra-glomerular shunt was most evidently demonstrated in the group of rabbits electrically shocked without previous treatment. and the adrenalectomized group with and without electric shock; while it was not evident in the group with autonomic blockade.
(4) Blockade of the renal autonomic nerves alone is inadequate for the prevention of shock, but it seems to have a certain measure of shock-preventing action by controling excessive vasoconstriction and pressor mechanism through the kidney.
(author's abstract)

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