J.Jpn. Surg. Soc.. 56(9): 1221-1232, 1955

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EXPERIMENTAL STUDIES ON THE PREVENTIVE EFFECT OF AUTONOMIC BLOCKING DRUGS FOR SHOCK

We studied the shock-preventing effect of pharmacological section of splanchnic nerve by using three kinds of autonomic blocking drugs ; Banthine, Tetraethyl-ammonium bromide and Hexamethonium bromide, based on the conclusion of our studies on the shock due to electric injuries.
Banthine reveals uncertain preventive effect for shock or rather increases the tendency to induce shock, because its parasympaticolytic action is predominant.
Tetraethyl-ammonium bromide has also preventive effect for shock, but the excessive administration reduces the effect due to remarkable parasympaticolytic action which is considered to counteracts sympathetic blockade concurrently induced by the drugs.
Hexamethonium bromide has stronger blocking effect to the sympathetic system than to the parasympathetic system. The administration by intravenous instillation is the most effective, because it prolongs the duration of action, economizes the dosage and reduces the side effects.
When shock dosis of electric current is applied to animals during hypotention induced by Tetraethyl-ammonium bromide or Hexamethonium bromide, the blood pressure is not aggravatedly reduced, but it increases gradually with the result that the animals survive from shock.
Even when reduction of the blood pressure is compensated by administratin such a vasotonic agent as Nor-adrenaline simultaneously with Hexamethonium bromide, the preventive effect for shock is not improved.
Controlled hypotention due to Hexamethonium bromide prevent shock because not only of reduction of the volume of bleeding, but also of blocking of the sympathetic system, especially the splanchnic nerve.
(author's abstract)

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