J.Jpn. Surg. Soc.. 56(4): 456-466, 1955

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FUNDAMENTAL RESERCHES ON THE CONTROLLED HYPOTENSION

Changes of cardiopulmonary function, splanchnic circulation and the effect of ganglion blocking agent in the experimental hemorrhagic shock have been observed in dogs.
The results are as follows :
1. In majorty cases cardiac output and splanchnic blood flow decreased temporarily at the beginning of hypotension but recovered after 60 minutes.
2. From the view point of the circulatory condition of hypotension, the limitation of the safetivity of hypotension degree is more than 40% in the average compared prehypotensive value.
3. By employing ganglion blockade 84% could be resuscitated in the experimental hemorrhagic shock but control showed the survival, only 40%.
4. However, under excessive hypotensive state there is a possibility of shifting to the irreversible shock owing to the slight exsanguination procedure.
Therefore, the indication should be established and the sufficient caution is required at the controlled hypotension.
(author's abstract)

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