J.Jpn. Surg. Soc.. 56(3): 368-381, 1955

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STUDIES ON IRON METABOLISM, ESPECIALLY ON FERRITIN IN THE LIVER

The author investigeted the action of Non-Hemin Iron in the liver, spleen and kidney, using the newly devised method. Experiments were made for 58 human surgical cases and 60 dogs.
Results in summary are as follows:
1. In case of surgical diseases except tumor cases the quantities of liver-ferritin is about 20% Non-Hemin Iron in the liver.
2. In case of splenomegaly, the Non-Hemin Iron accumulates in the spleen due to decrease of liver ferritin in the liver. With this result, the author assumes that, the anemia which will be generally found in this disease will be partly caused by ineffectiveness of Iron action in the spleen.
3. When the hepatic artery of experimental dogs is ligated, the ferritin decreases in the liver and increases markedly in the spleen and kidney.
Furthermore, it will be assumed from experimental results that penicillin prevents the transitor of Iron in the liver to some extent.
4. When injected CCl₄ in dogs, the ferritin in the liver decreases due to hepatic injury, and the value of the Bromsalphalein test is parallel to the quantity of the ferritin in the liver.
(author's abstract)

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