J.Jpn. Surg. Soc.. 56(3): 320-338, 1955
STUDIES ON THE SPLEEN FUNCTION AN INCREASED EXCRETION OF ARGININE IN THE URINE OF CERTAIN SPLENOMEGALY PATIENTS ESPECIALLY ACCOMPANYING BANTI'S SYNDROME
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2nd Surgical Dept., Osaka University Medical School (Director: Prof. M. Kuru) Akira SAITO |
2) Of 21 splenectomized cases of the same group, 13 cases had arginine in their urine completely disappeared on the very day of splenectomy or a few days postoperatively, 3 cases demonstrated no such abnormal excretion, 1 case turned positive in the abnormal excretion following splenectomy, and 3 cases were found positive pre-and postoperatively eventually turning negative in follow-up.
3) One case which had excreted arginine in excess came to put out a slight amount following X-ray irradiation. Sometimes it was found that the amount of increased arginine was gradually diminishing as anemia was recovering in response to measurement.
4) On the basis of paperchromatography and the measurement of the melting point a confirmation was made that flavianate which had been made from urine was arginine flavianate.
5) No relationship was observed, in Banti's syndrome patients, between abnormal excretion of arginine and erythrocyte or leucocyte count, liver function, portal pressure, duration of symptoms, stage of disease, weight of spleens and histological aspect of spleens.
6) An attempt was made to detect urine arginine as to 138 cases including disturbances in blood, liver, endocrine glands, kidney and gastrointestinal tract, etc. An abnormal excretion of arginine was observed only in some cases of blood disease and hepatic disease.
7) Banti's syndrome cases and familiar hemolytic anemia cases showed a decreas in erythrocyte count subsequent to subcutaneous administration of atropine, resulting in an increase in Sakaguchi's reaction positive substance of the serum and urine as well as in urine arginine. However, this findings disappeared following splenectomy.
Following subcutaneous administration of adrenaline and acetylcholine, both pre-and postoperatively, these patients showed no changes in Sakaguchi's reaction positive substance in serum and urine and urine arginine.
(author's abstract)
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