J.Jpn. Surg. Soc.. 56(2): 236-254, 1955
STUDIES ON THE ANTIDIURETIC SUBSTANCE
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2nd Surgical Department, Tokyo University School of Medicine (Prof. Seiji KIMOTO) Shigeomi OSONO |
1) By the modification from Inou's original method, the antidiuretic activity of serum, tissue extracts and urine is measured, resulting that the antidiuretic substance which appears in serum soon after stressors is identical with the antidiuretic hormone itself.
2) From both biological and histological assay, it is proved in any sort of surgical procedures that the neurosecretion of the antidiuretic hormone from the supraoptic and paraventricular nuclei, and the release of the hormone into blood stream from the posterior pituitary are stimulated for a definite period.
3) The antidiuretic activity in the hypothalamic neurosecretory nuclei and in the posterior pituitary runs parallel with the amount of the Gomori-stained substance in the same area, whereas runs reversally against the blood and urine level of the hormone.
4) The secretion of the antidiuretic hormone is proved in general to be mediated through the vagus-acetylcholine system, suggesting that the other rare secretory phenomena through ferritin, copper and iron ions will take place in surgery.
5) Both in vivo and in vitro, the liver can inactivate the antidiuretic hormone principally in the presence of the adrenal cortical hormone cortisone. However, soon after the surgery, the excretion of the hormone is accelerated from the kidney. There is no evidence of inactivation of the hormone in the kidney.
6) In any surgical operation, the antidiuretic hormone diminished the urine volume, reserves water and exaggerates the excretion of potassium significantly for a period. But the effect of the hormone on the metabolism of chloride and sodium is equivocal.
(author's abstract)
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