J.Jpn. Surg. Soc.. 56(2): 198-213, 1955
STUDIES ON BLOOD PICTURES IN SURGERY OF THE PORTAL SYSTEM, AND IN SURGERY OF THE SPLEEN
Part 2. THE HEMATOLOGICAL RESPONSE AND SPLENIC CONTRACTION BY ADRENALINE INJECTION
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2nd Surgical Department, Tokyo University School of Medicine (Director: Prof. KIMOTO) Kiyoshi MATSUI |
In splenomegalic patients the hematological response to adrenaline injection was more remarkable than in control patients and was mild within one month after splenectomy, then showed a nearly same response after one month as that shown before operation. Hemoconcentration due to adrenaline injection was proved by the method of blood volume estimation using Evans-blue, but it could not be explained why the degree of leucocyte increasing was greater than that of the other blood elements. Splenic blood obtained from removed spleen in operating room usually contained more leucocytes than the other blood elements.
There are many hypothesis in the hematological response to adrenaline injection, but the author believes that in splenomegalic disease the splenic contraction is one of the greatest factor for increasing blood elements. In splenomegalic disease, the degree of splenic contraction by adrenaline injection is influenced by 3 factors; namely, the change of arterial blood supply to the spleen, the condition of the spleen and the resistance of the splenic vein for the blood forced out from contracting spleen.
In Banti's syndrome, the degree of splenic contraction depends on the degree of splenic fibrosis, the splenic blood volume and portal pressure. In cases that showed remarkable splenic contractin by adrenaline injection, the splenic fibrosis was mild, splenic blood volume was great and the portal hypertension was often absent.
(austhor's abstract)
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