J.Jpn. Surg. Soc.. 56(2): 134-148, 1955

---

STUDIES ON FIBRINOLYSIS
Part 1: HEPATIC INSUFFICIENCY AND FIBRINOLYSIS
Part 2: REDUCED BODY TEMPERATURE AND FIBRINOLYSIS

1) In the case that showed intense hepatic insufficiency, such as liver cirrhosis and Banti's syndrome, sometimes severe postoperative hemorrhage was observed. The blood of such case was found to have increased fibrinolysis.
2) Fibrinolysis manifested during surgery was more frequent and intense in the case of impaired liver function than in that of normal liver function. This is one of the main cause of hemorrhagic state during operation in the case of hepatic insufficiency.
3) It was suggested that fibrinolysis in blood plasma depended on fibrinokinase in tissue. Since there were many differences in the degree of fibrinolytic activity among various tissues, the differences in the fibrinolytic activities of the blood plasma at the various locations in the body were investigated.
Hepatic and splenic blood showed weak fibrinolysis, or rather inhibitory effect on fibrinolysis. Renal blood and the blood of lower limbs showed strong fibrinolysis
In the case of impaired hepatic function, fibrinolytic activity of the blood plasma in every locations increased. It was not seen that only in the hepatic venous blood the fibrinolytic activity increased in such case.
1) When body was exposed to cold, fibrinolysis in blood became manifested. And the concentration of blood adrenaline increased remarkably, blood coagulation was delayed.
2) Under hibernation anesthesia with lytic cocktail, the concentration of blood adrenaline increased as same degree as simple exposure to cold, however, the degree of fibrinolysis was generally slighter.
3) The author discussed the mechanism and the biological significance of fibrinolysis under reduced body temperature.
(author's abstract)

---

---

To read the PDF file you will need Adobe Reader installed on your computer.