J.Jpn. Surg. Soc.. 56(1): 66-92, 1955
STUDIES ON THE PULMONARY CIRCULATION IN THE SURGICAL FIELD
Part I: A CLINICAL AND EXPERIMENTAL STUDY ON THE EFFECT OF ENDOTRACHEAL ANESTHESIA UPON PULMONARY CIRCULATION
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2nd Surgical Department, Tokyo University (Directer: Prof. S. KIMOTO) Yusaku ANAZAWA |
Following results were obtained :
1. Each anesthetics such as pentothal, nembutal, ether and nitrous oxide raised pulmonary arterial pressure. Especially under pentothal anesthesia the rise was remarkable. Pulmonary blood flow was reduced, but the reduction was not so marked by ether and nembutal.
Slightly increased total pulmonary vascular resistance, prolongation of pulmonary circulation time and increase of pulmonary blood volume were recognized under these anesthesia. These changes are due to the interference of pulmonary blood flow.
2. Lung collaps by the open pleura raised pulmonary arterial blood pressure and increased total pulmonary vascular resistance, blood flow of lung decreased.
3. Endotracheal positive pressure resulted in the remarkable disturbances, not only of the pulmonary circulation, but also of the peripheral venous system: raised pulmonary blood pressure, reduced pulmonary blood flow and rise in the venous pressure including right auricle.
Assisted respiration reduced the above mentioned circulatory disturbances of continuous positive pressure.
4. Hypoxia during anesthesia raised pulmonary arterial blood pressure, increased cardiac output and reduced pulmonary vascular resistance. This phenomenon was not remarkable under deep anesthesia.
5. Under general hypothermia pulmonary arterial blood pressure rised, pulmonary blood flow reduced, total pulmonary vascular resistance increased, and right auricular and peripheral venous pressure rised. Moreover, oxygen consumption decreased, arterial oxygen saturation did not reduced and arterial CO2 content increased.
(author's abstract)
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