J.Jpn. Surg. Soc.. 55(9): 997-1007, 1954

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Original article

AN EXPERIMENTAL STUDY ON THE INTRA-ARTERIAL TRANSFUSION
PART II. THE INVESTIGATION OF THE DIRECT INFLUENCE OF THE INTRA-ARTERIAL TRANSFUSION UPON CARDIAC AND CEREBRAL FUNCTIONS

The experiments were carried out so as to evaluate the direct effects of the intra-arterial transfusion on cerebral and cardiac action after the interception of the former blood flow followed by reinfusion into the carotid, vertebral, or femoral arteries. The methods of transfusion was same as those described in the previous report. The results were as follows :
1. Through clamping both carotid and vertebral arteries, arterial pressure rose remarkably, blood flow into the brain, however, was not completely interruped.
2. When the cerebral circulation was completely stopped, reinfusion into the cerebral arteries produced no recovery of respiration in the animals under advanced shock or cardiac arrest, although in some cases the cardiac beat was temporarily restored while in others without any reaction.
3. Saline infusion into cerebral arteries after complete occlusion of cerebral blood flow caused the instantaneous cessation of respiration and reflectory rise of arterial pressure. In the animals under hemorrhagic shock, when previously showed the rise in the arterial pressure by clamping cerbreal arteries, restoration of arterial pressure was produced following saline infusion. At that time by infusing diluted blood into the cerebral circulation, recovery of both respiration and arterial pressure was remarkable, especially the diluted venous blood was most effective, and that either infusion into the carotid or vertebral arteries resulted no distinguishable effect.
4. After cardiac arrest by stopping cerebral flow, transfusion with arterial blood into the femoral artery caused cardiac beat with rise of arterial pressure of two or five minutes duration, but no sign of respiration appeared.
Thus it has been demonstrated that the rapid intra-arterial as well as intravenous transfusion was equally effective possibly due to the direct effect on cardiac and cerebral action. Even under severe shock condition, so far as any cardiac and cerebral reactability still remaind, intra-arterial transfusion was assumed to have some advantage over intravenous transfusion.
(author's abstract)

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