J.Jpn. Surg. Soc.. 55(7): 815-827, 1954

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宿題報告

Pancreas Resection
(Mainly Against Fatty Liver)

Recent current of the visceral surgery researches seems to be much focused upon the problems of pancreas surgery or resection. Since several years before the author's interest, reflecting upon the question of fatty liver after the pancreas resection, was directed mainly toward the studies of fat metabolism which may play an important role in the liver, especially from the rpognostic standpoint of pancreas surgery.
The results obtained are as follows.
1) The dogs, when totally depancreatised, are apt to gain fat degeneration of the liver even under the adequate insulin administration, and expire mostly within 10 days. Nearly so it was with clinical cases.
2) Worsend functioning of the liver, when received total depancreatising, is to be observed definitely by means of functiomorphological findings of mitochondria devised by Prof. Takagi.
3) Resection of 4/5 portion of a pancreas may be admitted theoretically.
Out of the remaining 1/5 portion of the pancreas, the island cells regenerate more rapidly and the liver cells recover from fatty degeneration more or less.
Biopsy and post-mortem findings revealed similar results clinically and pathologically.
4) The modus of the original functions incident to the lipotropic factors under depancreatised body condition, may be summarised schematically as follows.
Hydrolysis Transmethylation
Protein---→Methionin--—→Cholin
Trypsin or Papain Vitamin B₁₂/(Co(cobalt)ion)
(The first stage) (The second stage)
Both stages mentioned above must be developed smoothly as the essential process of fat liver therapy in total depancreatising.
5) Simultaneous splenectomy during the operative techinique of pancreatectomy is apparently preferable with great prophylactic benefit avoiding pathological lipotropy, i.e., increase of survivals or lengthening of the life.
(author's abstract)

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