J.Jpn. Surg. Soc.. 55(7): 737-738, 1954

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Others

Vascular Studies of Gastric Ulcer and Gastritis

Roentgenographic pictures were made on excised stomachs of 200 patients after intravenous injection of Pb₃O₂₄, and histological studies were made by comparing the following stages of ulcer formation ;
1) Erosive gastritis, in which venous dilatation may be present without significant changes in the arteries.
2) Acute ulcer stage, with rather shallow ulcer of the mucosa, in which some decrease in arterial distribution, together with slight hypertrophy of the adventitia of arteries and dilatation of veins are noted.
3) Subacute ulcer stage, representing a stage just before the development of chronic ulcer, is characterized by very sparse disitribution and tortuosity of arteries. Histologically edematous hypertrophy of the adventitia of medium-sized and small arteries.
4) Chronic ulcer with callous formation, in which the arterial distribution is extremely reduced with marked tortuosity and the capillaris are absent. Histologically the walls of the large, medium and small arteries are greatly thickened with occasional obstruction. Intravenous emboli are also noted. This can be clearly differentiated from ulcerative carcinoma.
From these findings, it is clear that organic changes in the walls of medium and small arteries are present even in the fresh primary ulcer stage. These changes in the arterial walls became more intensified as the ulcer progress and become chronic.
(author's abstract)

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