J.Jpn. Surg. Soc.. 55(7): 706-714, 1954

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Others

The Development of Ulcer of the Alimental Tract and the Electro-chemically
Disclosed Local Disposition for Ulceration

A study of the metabolic changes which follow total gastrectomy inevitably led up to a study of the pathology of abnormal excitation of those functions which are characteristic of the stomach (ingestion of food, reservation of food, secretion of hydrochloric acid, excretion of blood-contained substances). It was ascertained as a result that ulcer of the alimental tract develops due to such abnormal functional excitation and through a consequent formal-genetic process in the form of inflammation. It was also demonstrated that it is unreasonable to pay attention exclusively to hydrochloric acid in the study of ulcer : that hydrochloric acid has a significance of its own which is definable from a histological and causal-genetic point of view ; that the alimental tract is varied in biological local disposition in its diferennt parts. Further, it was numerically confirmed in a special electrochemical investigation that the mucosa of the alimental tract is locally different in sensitivity to hydrochloric acid. Local disposition for ulceration, a subject so far left as a scientific blind spot, was thus elucidated.
(author's abstract)

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