J.Jpn. Surg. Soc.. 55(4): 414-422, 1954

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Original article

STUDIES ON THE CONCENTATION OF PENTOTHAL SODIUM IN PLASMA AND TISSUE

1. A method was described for the estimation of Pentothal Sodium in plasma and tissues. After intravenous administration of Pentothal Sodium to dogs and mice, its concentration was estimated in plasma and tissues in order to study the changes of its distribulion in the body.
2. As its excretion and transformation is slow, the fact that Pentothal Sodium is short-acting, cannot be explained. Repeated intravenous administration of it to a dog was followed, by accumulation of Pentothal Sodium.
3. After its intravenous administration, Pentothal Sodium was distributed to all tissues very rapidly. At first, its concentration in brain tissue was higher than in plasma and in fat. But, its concentration in only fat tissue rose rapidly, whereas the concentration of the drug in other tissues declined rapidly.
4. The fact that the drug is short-acting, was explained by the changes of its distribution in the body.
5. While the anesthesia was maintained, intra-arterial plasma concentration was higher than that of vein, but this phenomenon was reversed when animal is awaken. These results were explained as a part of mechanism of anesthesia mentioned above.
(author's abstractr'

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