J.Jpn. Surg. Soc.. 55(4): 385-395, 1954
Original article
STUDIES ON INTRAARTERIAL APPLICATION OF METHYL-(BIS-β-CHLOROETHYL)-AMINE-N-OXIDE AND ISOAMYL-(BIS-β-CHLOROETHYL)-AMINE-N-OXIDE AGAINST MALIGNAT TUMOR
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I. Surgical Department, Tokyo University School of Medicine (Director: Prof. K. Shimizu) Takuji NAKAMURA |
Against malignant tumors of man intraarterial injection of NMO and A-NMO was performed, which showed much better effect than intravenous injection.
Before and during the therapy, serial needle biopsy was performed in order to trace cytological changes of tumor by smear preparate. The cytrological changes, namely, abnormal mitosis, appearance of giant cell, vaculolar degeneration, nuclear deformity, etc., which may be due to disturbance of mitosis, were observed.
NMO was injected into the femoral artery of rat before tumor-formation of Yoshida Sarcoma which was transplanted subcutaneously in the calf region. When inhibitory effect of intraarterial injection against tumor-formation with that of intravenous injection, the former is far more excellent than the latter.
Considering the marked difference of the effect mentioned above, it is thought that injecthd NMO is not absorbed gradually into tissue remaining in circulating blood, but is absorbed rapidly.
Accordingly, for the purpose of postoperative control of recurrence or palliative treatment, intraarterial application of NMO, and A-NMO as tumor-growth retarding agents is more effective than intravenous application.
(author's abstract)
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