J.Jpn. Surg. Soc.. 55(1): 51-59, 1954

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Original article

EXPERIMENTAL STUDIES ON THE INFLUENCE OF HYDROCHLORIC ACID UPON THE SECRETION OF PANCREATIC JUICE AND BILE

As total gastrectomy deprives the organism of hydrochloric acid, an important factor for its existence, altogether and forever, we thought it necessary to ascertain what influence the same substance given orally after total removal of the stomach exerts on the secretion of pancreatic juice and bile and in what concentration the substance given works best for the purpose. By way of experiment, we introduced hydrochloric acid into the dog duodenum and examined the result. The conclusions reached therefrom were as follows.
1) The concentration in which hydrochloric acid increases the secretion of pancreatic juice and bile is over 0.1% at the lowest.
2) 0.2% hydrochloric acid is far more powerful than the artificial gastric juice and 0.1% hydrochloric acid in promoting the secretion of pancreatic juice and bile, but it is difficult to find out any remarkable difference in that effect between 0.3% and 0.2% hydrochloric acid.
3) This response to hydrochloric acid is very manifest in subphrenically vagotomized dogs and totally gastrectomized dogs as well as in normal dogs. The secretion begins in less than 5 minutes after the introduction of hydrochloric acid into the duodenum.
4) These results seem to indicate that it is most reasonable for patients surviving after total removal of the stomach to take orally 0.2% hydrochloric acid just before meals.
(Authors' abstract)

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