J.Jpn. Surg. Soc.. 55(1): 21-31, 1954
Original article
SURGICAL APPILICATION OF URETHANE
PART I. ON THE BACTERIOSTATIC-BACTERICIDAL EFFECT, TOXITY AND THE TISSUE REACTION OF URETHANE
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Surgical Department, Tokyo Police Hospital (Chief: Dr. H. Yoshioka) Toshishige WAKABAYASHI |
Its bacteriostatic concentration is from 2.5 per cent to 5 per cent, the bactericidal concentration being from 5 per cent to 10 per cent.
2) The tissue permiability of urethaue is not remarkable.
3) The bactericidal effect of urethane is very little affected by the solvent's pH and not affected by heat, light and so on.
The cooperative action of urethane and penicillin is not marked in vitro, but so noticeable in vivo that the bactericidal time for suppurative organisms is remarkably shortened.
Penicillin-fast organismus are much more sensitive to urethane than penicillin-seusitive strains are.
5) The bactericidal effect of urethane can be increased by adding serum to the media.
6) The bactericidal time of 10 per cant solution of urethane is longest about 12 hours for staphylococci, hemolytic streptococci and hyphomyceten.
7) The urethane has no such proteolytic action as the urea does.
8) The minimal lethal dosis of urethane in rabbits is 1.5 gm per kgm. body weight in intravenous injection, 2.5 gm per kgm body weight in intraabdominal injection, and about 2.0 gm per kgm body weight in subcntaneons injection.
9) The injection of 10 per cent solution of urethane causes mild inflammation and hemorrhage in the skin and subcutaneous tissues which heals with fibrosis after 7 days, but no damage in the muscle tissues.
(author abstract)
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