J.Jpn. Surg. Soc.. 55(1): 11-20, 1954
Original article
AN EXPERIMENTAL STUDY ON THE FAT OF SPLENOTOXIN AFTER REMOVAL OF SPLEEN IN CASES OF SPLENOPATHIC TOXICOSIS (TOMODA)
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2nd Surgical Clinic, Faculty of Medicine, Kyushu University (Director: Prof. Masanobu TOMODA) Shigechika TAMURA |
1. Is splenotoxin detectable in the liver after removal of the spleen?
2. Does an anemia.causing agent exist in the peripheral blood of a patient of splenopathic Toxicosis (Tomoda) after removal of the spleen?
Experiment 1. The hepatic branch of the splanchinic nerve was cut in rabbits when a certain period of time after removal of the spleen, the liver was considered to be acting compensatorily for the loss of splenic function. The animals were killed a certain period afterwards and an extract prepared from their livers was successively injected into normal rabbits. The blood picture and hepatic function of the animals given the extract were examined.
Result: No occurrence of anemia detected in the blood picture, no functional disturbance recognized in the liver-function test.
Experiment 2. The peripheral blood-serum of 4 patients of splenopathic toxicosis who had their spleens removed long before, was injected into normal rabbits.
Result: No anemic condition was observed in all the cases.
These experimental results and the tetal disappearance of preoperative pathologic conditions after removal of the spleen in patients of splenopathic toxicosis, seem to make it safely confirmable that the liver does not produce splenotoxin or any substance approaching it after removal of the spleen in cases of this disease.
(author's abstract)
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