J.Jpn. Surg. Soc.. 54(12): 1134-1141, 1954
Original article
HISTOLOGICAL STUDIES ON THE EXPERIMENTAL OSTEOMYELITIS
PART I. THE MECHANISM OF THE DEVELOPMENT OF OSTEOMYELITIS
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Anatomical Laboratory of Prof. M. Yamasaki, Medical Faculty, Tohoku University Shinobu TAKEYAMA |
1. In both cases the primary reaction field is constituted from 4 layers.
2. In aseptic cases these layers undergo degeneration, and after 36 hours they are substituted for granulation tissue by activity of the granulocytes; and it transforms into scar tissue later. During all of these processes surrounding bone marrow supplies granulocytes to the inflammatory field, however, indicates no specific tissue reaction.
3. Also in purulent osteomyelitis, 4 layers mentioned above are substituted for granulation tissue by activity of the granulocytes. At the same time, however, cocci invade into surrounding bone marrow and it changes to granulation tissue.
4. Mechanism of the formation of granulation tissue is explained monistically by the potency of the granulocytes, but also myelocytes, pro-and metamyelocytes participate in this case. Differentiation of these granulocyte series is direct and indirect transformation into fibroblasts. Intermediate forms in indirect transformation are monocyte, histiocyte, lymphocyte and plasma cell. Appearance of the latter two types are numerous in burulent osteomyelitis.
(author's abstract)
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