J.Jpn. Surg. Soc.. 54(12): 1079-1090, 1954
Original article
A STUDY BY EXPERIMENTAL PERFUSION ON THE CHARACTERISTIC NATURE OF SPLENIC FUNCTION CONCERNED WITH ANEMIA-CAUSING ACTION
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The Second Surgical Department, Faculty of Medicine, Kyushu University (Director: Prof. Masanobu TOMODA) Hisashi YOSHITOSHI |
I) The liquid obtained after perfusion through the spleen with the extract of the spleen or the liver has an anemia-causing action, whereas the liquid obtained after perfusion through the spleen with the extract of the bone marrow, kidney, lung and brain has no such action. The fact indicates that, of the above-mentioned extracts, that of the spleen and liver alone can act on the spleen as a stimulus provoking an anemia-causing action.
II) The fluid obtained after perfusion through the spleen with the spleen-extract has an anemia-causing action, but the fluid obtained after perfusion through the liver, bone marrow, kidney or lung with the same extract has no such action. The liver-perfused fluid with the liver-extract has such action either. It therefore follows that of the organs mentioned above the spleen alone can be a stimulus-inducing body by which an anemia-causing action is started in response to the anemia-causing stimulation. The liver in particular is considered to have the same function as the spleen as a stimulus provoking an anemia-causing action, and to act in spleen-exstirpated animals as stimulus-inducing body by which an anemia-causing action in started compensatorily in spleen-exstirpated animals. However, no function of a stimulus-inducing body by which an anemia-causing action is started is recognizable in the liver of any normal animal with its spleen unremoved.
III) In short, a function similar to that of the reticuloendothelial system of the spleen with a stimulus-inducing body by which an anemia-causing action is started, is uniqe and not to be found in any other organ.
(author's abstract)
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