J.Jpn. Surg. Soc.. 54(11): 1016-1028, 1954

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Original article

VASOTROPIC FACTORS IN SOME EXPERIMENTAL SURGICAL CONDITIONS AND IN SURGICAL OPERATIONS
Part 2. Vasotropic factors in surgical operations.

In 9 cases of acute appendicitis, 2 fell into shock due to spinal anesthesia in whom vasotropic factors appeared transiently. In 9 cases of gastrectomy for peptic ulcer VEM appeared from during operation to 3 hours after that. In a severely invaded case VEM persisted for more than 3 hours and disappeared in 10 hours. In each case of a subclavian fracture and a femoral fracture no vasotropic factors could be demonstrated. In 3 cases of head injury VEM appeared from time to time, while in a mortal case VDM appeared with other symptoms of irreversible shock. In 3 cases of cholelithiasis or cholecystitis I case with impaired hepatorenal function showed VEM from during operation to 3 hours later. Forteen cases of thoratic operations were studied. In 4 cases of thoracoplasty whose blood-loss reached 10 cc per kg. of bodyweight, VEM was demonstrated from during operation to 3 hours or 6 hours after that. Five cases of acute perforation-peritonitis were observed. Those who losed considerable time before treatment and one of duodenal perforation showed VEM already before operation. When fallen into severe shock during operation, VDM appeared temporalily, which was replaced by VEM as patient recovered, thereafter, VEM was found for long time postoperatively. In mild cases VEM appeared transiently or never.
(author's abstract)

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