J.Jpn. Surg. Soc.. 54(9): 786-797, 1953

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Original article

STUDIES ON THE EFFECT OF THE DRAINAGE ON THE ACUTE PERITONITIS

The author has done many experiments about the efects of the drainage on the acute peritonitis on rabbits and mice, and found that it has the biological efects other than the effect of draining pus.
1) The drainage in the peritoneal cavity developes the fibrin formation. There occurs much more fibrin in the inflammated peritoneal cavity with the drainage than the one wi without the drainage. The drainage has influenced on the movement of the bowel and promoted the localization of the inflammation.
2) The fibrin fixes the bacteria and the dyes when it forms, which will be dealt slowly with the white blood cells afterwards, inhibits the absorption of them to protect the living body from noxes and plays a important rôle to localize the inflammation and to promote the adhesion of the various organs in the bowels.
The drainage is favorable on account of the promoting efects to the developement of the fibrin.
3) The rate of absorption in the general inflammated peritoneal cavity decreases near and at the drain, but increases all over the other general peritoneal cavity.
4) There appear much of the glucose-dehydrogenating enzymes in the inflammated peritoneal cavity, which increase with the drainage in it.
5) The secretion in the inflammated peritoneal cavity containes the spreading factor and the promoting factor of the permeability of the vessels. These factors show the same tendency after the drainage during 5 hours as the controls and the decreasing tendency after the drainage during 48 hours as the controls. Both factors do not always go parallel.
The secretion in the inflammated peritoneal cavity after the drainage during 5 hours promotes the localization of the inflammation caused by staphylococci injected intracutaneously. (author's abstract)

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