J.Jpn. Surg. Soc.. 54(8): 703-712, 1953

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Original article

CLINICAL STUDIES ON WOUND HEALING, ESPECIALLY ON THE RELATION BETWEEN PROTEIN DEFFICIENCY AND WOUND HEALING FAILURE OF GASTROINTESTINAL ANASTOMOSIS

According to the plan to study the cause of wound healing failure, I have studied clinically on the relation between protein defficincy and wound healing failure of gastrointestinal anastomosis. In this studies, the authnr has examined following items concerning the patients suffering from gastric cancer and gastric or duodenal ulcer, who are subjected to gastrectomy; (1) observation of postoperative clinical progress, (2) estimation of concentration and circ ulating mass of haemoglobin, serum protein, serum albumin and serum globulin, immediately before the operation, (3) estimation of portions of tissue water and tissue protein (total protein, soluble protein and unsoluble protein) of resected gastric walls.
By the summarization and analysis of obtained data, the author has found several con clusions as follows:
(1) The failure of wound healing in gastrointestinal anastomosis occurres absolutely frequent in case of gastric canser in comparison with gastric or duodenal ulcer.
(2) It is recognized that cancer patients tend to develop into protein deffidency, correctly hypoalbuminism on the whole body in comparison with ulcer patients.
(3) Hypoalbuminism on the whole body is a important factor of the wound healing failure in gastrointestinal anastomosis, too.
(4) The level of hypoalbuminemia tend to disturb the wound healing is under 2,5 grams per 100 cc. Therefore, it is important to prevent the wound healing failure, that the concentration of serum albumin of the patient expected to subject to operation is elevated over 2,5 grams per 100 cc. by the preoperative treatment. (Author's abstract)

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