J.Jpn. Surg. Soc.. 54(5): 367-373, 1953

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Original article

EXPERIMENTAL STUDIES ON PHARMACOLOGICAL ACTION OF 1-METHYL-4-PHENYL-PIPERIDIN-4-CARBOXYLIC ACID-ETHYL ERSTER

This drug has been used as analgesic and basal anesthetic for these several years in our department and has proved to be effective. But as for the pharmacological actions, there remains many points to be clarified. The author made the following experiments concerning these points. First the lethal dose was examined for the guineapig and rabbit by various ways of administration, Next the therapeutic dose was determined, and the conditions of experimental animals being observed.
The results were as follows:
1) Effects upon respiration, heart and blood pres sure by intravenous injection.
The rate and amplitude of respiration decrease and the inspiratory phase is prolonged The rate and amplitude of the heart beat increase and the blood pressure drops.
2) Vitacampher, Lobelin, Coramin have antagonistic action against respiratory effect of this drug, and Vitacampher, Lobelin, Atropine reduces its effect upon the heart, and Vitacampher, Ephedrine decrease its effect up on blood pressure.
3) When administered intra arterially, it increases rate and amplitude of respiration, and prolongs the inspirium and decreases blood pressure. It increases cardiac amplitude, but does not increase its rate.
Compared with the intravenous administration, intra-arterial injection has less marked influences upon respiration, heart beat and blood pressure and the injected animal shows a quicker recovery to the condition before administration.
4) The intestinal movement is suppressed after a short phase of activation and then again highly activated until it gradually returns normal.
5) It prevents anaphylaxis and anaphylactoid phenomena caused by horse serum, acetylcholine or histamine. (author's abstract)

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