J.Jpn. Surg. Soc.. 54(5): 359-366, 1953
Original article
LOCAL APPLICATION OF THE CHLOROPHYLL(Ch) FOR THE WOUND HEALING
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I. Surgical Department, Tokyo University (Director: Prof. K. Otuki) Sho IIDA |
I) At first the author revealed, as a result of a few physico-chemical experiments, that the Ch, used in this study, was rough material.
II) The clinical observation on the Ch applied cases:
1) In 77% of the fresh wounds, there were better healing course and tendency to heal quickly by means of the considerable decrease of secretory fluid.
2) Out of the wounds of delayed healing, 50% of all cases had the tendency to heal rapidly, within two days, 52% became the good granulation-tissues and 43% decreased its secretory fluid remarkably.
3) Compairing the Ch with Rivanol which were separately applicated on the other wound of the same patient, the former was more effective.
4) After application of the Ch from 24 h to 48 h. young leucocytes increased and reversely the destroyed cells decreased in the secretory fluid from wounds.
III) The results of the biological and experimental studies on the Ch were as follows:
1) The Ch had no harmful effect on the phagocytosis of leucocytes, moreover it increased the function of R. E. S.
2) The Ch did not irritate the conjunctiva of rabbit except for only temporary hyperaemia.
3) The bacteriostatic effect on the staphylococcus was slightly proved by 0.5% solution and completely by 1% solution. The streptococcus was inhibited its growth completely by even 0.1% solution, but B. colli was responsible not at all.
4) The Ch dilatated adequately the capillary blood vessel of the frog and improved its blood stream.
Conclusion : The auther proved the following pharmacological action of the Ch; 1) the slight bacteriostatic effects, 2) increasing the function of histiocytes in granulation-tissue, 3) improvement of the blood steam due to adequate dilatation of cappillary blood vessel, and 4) the remarmarkable appearance of younger leucocytes in the secretory fluid. According to these effective results the auther concludes that by the Ch the wound surface are rapidly cleaned up, granulation-tissue are improved, and then the wound heals quickly.
(author's abstract)
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