J.Jpn. Surg. Soc.. 54(2): 134-148, 1953
Original article
A CLINICAL STUDY ON THE HEPATIC DYSFUNCTION AND LIVER PROTEIN lN RELATION TO SURGICAL OPERATIONS.
Part 2. LIVER PROTEIN
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Surgical Department, Tokyo University Branch Hospital (Director: Prof. T. FUKUDA and T. HAYASHIDA) Maki SAKAMOTO |
In 76 patients studied, liver protein exceeded 13gm% only in 14 cases (18.4%). It was lower in stomach cancer than in gastric ulcer, and lower in inoperable cases than in resectable cases. Albumin fraction decreased usually in pararell with decrease of total protein, under 10gm% of which albumin decrease decerelated.
Between liver protein and plasma protein existed close correlation. They were divided into 3 groups : 1) with both normal plasma protein and normal liver protein, 2) with normal plasma protein and depleted liver protein, and 3) with both depleted plasma and liver protein. Depletion of protein was accerelated during the course of operation.
Patients with depleted liver protein suffer a high incidence of hepatic dysfunction than with normal.
Liver protein and its albumin fraction decreased during surgical procedures without exception and α-globulin fraction increased in most cases as if it were the replacement of albumin.
In 17 patients who were given whole blood during operative procedures, 3 showed increase of liver protein and 4 showed increase of albumin fraction in postoperative specimens. In 13 patients who were given casein hydrolysate during operation, 5 showed increase of albumin fraction. Use of whole blood and casein hydrolysate seemed to diminuish liver protein depletion.
(author's abstract)
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