J.Jpn. Surg. Soc.. 53(11): 898-903, 1953
Original article
ON EXPERIMENTAL SPLENIC ANEMIA-CAUSING FACTOR WITH SPECIAL REFERENCE TO ITS DIFFERENCE FROM SPLENO-TOXIN OF THE PATIENT WITH SPLENOPATHIC TOXICOSIS
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Second Surgical Clinic, Faculty of Medicine. Kyushu University (Director: Prof. M. TOMODA) Atsushi TETSUO, Yoshitoshi TAKI, Kunihiko OKADA |
1) The presence of a thermostable anemia-causing factor in the spleen of the patient with splenopathic toxicosis was demonstrated by the result of our perfusion experiment on the dog's spleen using physiological saline extract (warmed for 30 minutes at 80°C) of the said patient's spleen.
2) No thermostable anemia-causing action was observable in the fluid perfused through the dog's spleen, when physiological saline extract (warmed for 30 minutes at 80°C) of the normal dog's spleen in a concentration twice as high as in the case of splenopathic toxicosis was used for perfusion.
3) Spleen-perfusion experiments in the dog with two kinds of extract (warmed for 30 minutes at 80°C) of the normal dog's and ox's spleen in a concentration eleven and twelve times respectively as high as in the case of splenopathic toxicosis, demonstrated the occurrence of a thermostable anemia-causing factor in the perfused fluid of normal spleen.
4) A Long-range injection experiment proved that the above mentioned thermostable anemia-causing factor experimentally produced in a normal spleen causes no disturbance of liver function.
The above-stated observations appear to make it conceivable that the anemia-causing factor experimentally produced in normal spleens by the authors was in quality not the same substance as spleno-toxin of the patient with splenopathic toxicosis.
(authors'abstract)
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