J.Jpn. Surg. Soc.. 53(11): 868-879, 1953
Original article
STUDIES ON THE WATER METABOLISM Ⅱ. ON THE FACTORS INFLUENCING THE BODY FLUIDS EXCHANGE
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2nd Surgical Department, Tokyo University Medical School (Director: Prof. T. Fukuda) Kazuhiro KODEKI |
1) Extracellular fluid volume decrease in such conditions as hunger and abnormal water deficit, but circulating plasma volume is there by usually constant: in the respect the adrenal cortex seems to play an important role.
2) Water contents in vascular compartment increase when plasma protein concentration rises and total circulating plasma protein recovers in parallel to the improvement of circulating plasma volume.
3) In the short time after transfusion the blood becomes diluted. Repeated transfusions of small amounts increase the level of plasma protein.
4) By the administration of saline solution, water is retained. In this connection, vascular water contents expand more extensively than extracellular fluid, and muscle water contents reach their highest value in 24 hours after injection.
5) Glucose injection retains smaller water than infusion of Ringer's solution and glucose does not increase extracellular fluid volume in unneccesary way but the circulating red cell volume may increase.
6) The activity of water excreation in glucose injection is more remarkable than injection of Ringer's solution, clinically and experimentally.
7) After the adminitration of hypertonic glucose solution over 40ml/kg animals are fatal usually. General cause of death is lung edema.
8) Both anterior and posterior pituitary hormones increase body fluid.
9) DOC injection increase body fluid the increase of plasma volume is connected with increase of plasma protein.
10) Tissue fluid contents in the injection of ACE is closely connected with tissue protein contents.
11) In the injection of ACE, body fluids and plasma protein increase. Preoperative injection of ACE may correct the dehydration and prevent the operative shock, so that preoperative injection of ACE seems to be useful in adrenocortical insufficiency.
(author's abstract)
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