J.Jpn. Surg. Soc.. 53(11): 851-867, 1953

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Original article

PATHOLOGICAL STUDIES ON THE LIVER-TISSUE AT THE PRINCIPAL SURGICAL DISEASES OF ABDOMINAL BOWELS, AND ESPECIALLY ON THE CORRELATION BETWEEN THE QUANTITATIVE CHANGES OF GLYCOGEN AND FAT IN THE LIVER AND ITS FUNCTlONS. (Part. 2)

(5) In human case, the distribution of glycogen in the liver-acinus on the state of starvation is divided into 3 categories: in the case of large amount of glycogen it shows generally equal diffuse distribution, in the case of medium amount it shows generally peripheral, but unusually central distribution, and in the case of small amount it shows irregular circumscribed distribution. In other words, the dissimilation of liver-glycogen, on the state of starvation, begins usually at the central zone of acinus, but it begins unusually at the peripheral zone.
(6) The appearance of glycogen in the nucleus of the liver-cell about which was discussed variously and that of glycogen and fat out of the liver-cell were recognized in vivisectional specimens of the human liver, too. Consequently it is proved that not all glycogen out of the liver-cell is prodused by postmortem change.
(7) On the state of starvation, mitochondria of normal liver-cells of the mankind present minute short bacilliform in case that the liver-cell involves a small or medium amount of glycogen, while they are connected with each other and are roughly messed in case that the liver-cell involves a large amount of glycogen. But mitochondria change directly after death.
(8) The histological findings of the vivisectional specimen of human livertissue, except mitochondria and glycogen, differ from those of the cadaver-liver in next points: the livercells, in the former case, swell with sufficient turgor, the lumens of the capillary bloodvessels are narrow, the quantity of blood is little, and the infiltration of lymphocytes in in-terstitium is intensive. (author's abstract)

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