J.Jpn. Surg. Soc.. 53(10): 784-802, 1953

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Original article

PATHOLOGICAL STUDIES ON THE LIVER-TISSUE AT THE PRINCIPAL SURGICAL DISEASES OF ABDOMINAL BOWELS AND ESPECIALLY ON THE CORRELATION BETWEEN THE QUANTITATIVE CHANGES OF GLYCOGEN AND FAT IN THE LIVER AND ITS FUNCTIONS.
(Part 1.)

On 122 cases of the principal surgical diseases of abdominal bowels (1. cancer of stomach: 65 casee, 2. cancer of the digestive system except stomach and liver: 7 cases, 3. gastric and duodenal ulcer etc.: 27 cases, 4. biliary tract diseases: 11 cases, 5. liver disease: 5 cases, 6 other diseases: 7 cases) I performed the liver-function tests, applied various defensive treatments of the liver and observed the results. At the same time I made a thin section of the liver at each operation and performed histological researches. Thus I acquired the following results.
(1) Generally, the state of damaged liver-functions was not particularly different from the reports of many authors, and this damage recovered to a certain degree by the preoperative defensive treatments of the liver. From the facts that the results of the clinical liver-function tests recovered and that glycogen increased in the liver-tissue, I recognized that at the defensive treatments of the liver the supply of protein by blood-and plasmatransfusion etc. was more effective than the injection of vitamine-and glucose-solution. Especially it is just so in the case of cancerous cachexy and liver cirrhosis. The liver-fat, being different from glycogen, is slow in quantitative changes and is not intensively influenced by the defensive treatments of the liver.
(2) In the liver-tissue, generally, exist various kinds of pathological changes in proportion to the degree of the damaged liver-function, and most of them do not much differ from what many authors have found already in the liver of the human cadaver. But as the special findings I recognized the existence of leucocytes in the liver-cells and the marked hyaline droplet degeneration in a few cases.
(3) Under the same condition the state of liver-function is nearly parallel with the quantity of glycogen, but on the other hand the quantity of glycogen, but on the other hand the quantity of liver-glycogen varies as the kind of disease and the state of nutrition. The quantity of glycogen, generally, is large at liver and biliary tract diseases (chiefly at liver cirrhosis), but small at consumptive diseases like gastric cancer, etc.
(4) The percentage of the appearance of liver-glycogen of the vivisectional specimen is generaliy larger than that of the liver-glycogen of the cadaver. But in my case, owing to the intensive damage of digestion and absorption, the quantity of glycogen is nearly or less in comparison with that of the cadaver at general diseases. It is nearly so in the case of liver-fat.
(author's abstract)

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