J.Jpn. Surg. Soc.. 53(10): 775-783, 1953
Original article
THE EFFECT OF INTRAVENOUSLY ADMINISTERED CASEIN DIGEST ON GASTRIC SECRETION AND ITS MECHANISM.
|
1st Surgical Department, Tokyo University Medical School (Director: Prof. Kentaro SHIMIZU) Susumu HOJO |
The results obtained are as follows :
(1) Casein digest, administered intravenously, stimulated gastric secretion in 75 per cent of human tests.
(2) This effect was reduced but was not completely inhibited by atropine, vagotomy or by mixing the casein digest with a dextrose solution.
(3) Most amino acids contained in casein digest stimulated gastric secretion when administered intravenously, especially the effects of glycine, phenylalanine, lysine, aspartic acid and glutamic acid were remarkable.
(4) The content of histamine-like substance in 5 per cent casein digest solution tested varied from 1.4 to 2.8 micrograms per cc. (average 1.9 micrograms per cc.).
(5) Stimulation of gastric acid formation is accompanished through both a relatively high histamin-like substance content and amino acids content in casein digest, the former by the direct stimulation of the gastric gland and the latter by the stimulation of the vagus nerve center.
(author's abstract)
To read the PDF file you will need Adobe Reader installed on your computer.