J.Jpn. Surg. Soc.. 53(10): 743-754, 1953

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Original article

INTRAPERITONEAL USE OF SULFADRUGS, ANTIBIOTICS AND UREA

The author studied the influence of sulfadrugs, antibiotics and urea on the intestinal movement and peritoneal conditions. In these experiments, the abdominal window made by resin and inkwriting recording in Magnus method were used.
Sulfadrugs, administered directly into the peritoneol cavity, stimulate the serosa and inhibit the movements of the intestine. These phenomena are especially demonstrable when the powder of such drugs are used. But, exceptionally, water-soluble marphanyl has no such effects.
In antibiotics, penicillin has no such effects but another antibiotics such as aureomycin and terramycin act as stimuli locally and inhibit the movements of the intestines.
Urea shows more violent stimulation than others and causes severe hemorrhage and adhesion of the serosa where the drug is applied.
Paraamino-salicylic acid and colistin have no such similar effect.
As regards to the mechanisms of such drugs, it may be concluded from these experiments that drugs which inhibit the movements of the intestine act more or less upon the extra-intestinal nerves.
In these experiments, the author concludes that the direct admininstration into the peritoneal cavity of all sulfadrugs and antibictics except penicillin and marphanyl solution should be avoided.
(author's abstract)

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