J.Jpn. Surg. Soc.. 53(4): 265-273, 1952
Original article
STUDIES ON THE COMBINED USE OF UREA AND SULFATHIAZOL.
II. ON THE ABSORPTION, EXCRETION AND DISTRIBUTION IN BODY TISSUES AND INFLAMMATORY AREAS OF SULFATHIAZOL, WHEN USED WITH UREA SIMULTANEOUSLY
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The 2nd Department of Surgery, Tokyo University, Japan Fumiyoshi IIDA |
(1) Blood levels of sulfathiazoles are lower than that in the group of sulfathiazol alone. This effect is attributed neither to delayed absorption nor to accelerated excretion.
(2) In body tissues sulfathiazol is highly concentrated.
(3) Urinary level of sulfathiazol is more reduced as urinary volume increases, and the drug is more soluble as urinary concentration of urea rises: These two factors seems to inhibit the development of renal injury.
(4) Tissue level of sulfathiazol increases also in the inflammated area, for this phenomenon the increase of capillary permeability by urea will be an important factor. The concentration of urea in the central portion of inflammatory area is the same as that of bloodplasma. As the author demonstrated in the Ist report, urea prevent the antagonistic : activity of pus against sulfonamide. The clinical results of intensified antibiotic action of sulfadrugs by the combined use of urea should be attended to the increased tissue concentration of drug, and at the same time to preventing the antagonistic activity of pus against sulfadrugs.
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