J.Jpn. Surg. Soc.. 53(4): 216-224, 1952

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Original article

AN EXPERIMNTAL STUDY ON THE ALLERGIC ETIOLOGY OF ARACHNOIDEAL ADHESION (Part II)

1) The author was successful in producing allergic histologic changes in the brain arachnoid by reinjecting binding-zone quantity of antigen serum into a carotid artery of a rabbit which had been sensitized by the injection of cow serum through its ear vein.
2) By this experiment, the brain arachnoid indicated the 3rd type thickening (the arachnoid of inflammatory cell infiltration) at first. As the time went on, the thickening gradually changed to 2nd type (Proliferation of trabecula cells) and 1st type (Proliferation of covering cells). Meanwhile the author witnessed adhesions of arachnoid with pia mater or dura mater encephali.
3) The areas where allergic histologic changes constitute the brain arachnoid are believed to occur more frequently than the rest of body at the cisterna chiasmatis, cisterna cerebelli dorsalis, cisterna intercruralis, cisterna cerebellomedullaris, cisterna ambiens, cisterna valleculae cerebri lateralis and front convex portion of brain, which are enumerated by the order of frequency. It is very likely to grow at such an area as with plenty blood-vessels and stationing of cerebrospinal fluid. This phenomena are quite analogous to the clincal changes of arachnitis adhesiva cerebralis of men.
4) The intensity of histologic changes of brain-arachnoid shows no relation with the reinjected antigen quantity but seemingly depends on the diluted antibody titer.
5) At the 2nd group where antibody titer is larger than the others, the changes appear earlier and stronger with a longer lasting symptom than the 1st group in which antibody titer is small.
6) From the foregoing results, the author has concluded that allergy may also happen to the arachnitis adhesiva of men. (author's abstract)

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