J.Jpn. Surg. Soc.. 53(3): 143-148, 1952

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Original article

A STUDY ON THE SOFT, ABSORBABLE INSERTING SUBSTANCE USED IN SURGERY. (8) THE EXPERIMENTAL STUDY ON THE CALCIUM-AND ALUMINIUM ALGINIC ACID GEL INSERTED IN VIVO.

The calcium-and aluminium alginic acid gel were basically studied by insertion into the muscle of rabbits to determine their absorbability. The salt gel causes reaction normally observed in the course of granulation tissue formation and it is almost organized in 4 weeks, but in its irritability, aluminium is more severe than calcium gel. Though alginic are now being utilized in therapeutic as the new effective hemostatic as same as oxy-cellulose, gelatin-sponge, and fibrinfoam, it is interesting to note that alginic acid is capable of controlling the mechanism and the rate of absorption not only physico-chemically but also biologically by the various salts.
It is my belief that by improving these salt gel it is possible to employ them as soft, absorbable substances in surgery. (author's abstract)

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