J.Jpn. Surg. Soc.. 53(2): 82-90, 1952

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Original article

A STUDY ON THE SOFT, ABSORBABLE INSERTING MATERIAL USED IN SURGERY (7) : THE EXPERIMENTAL STUDY ON THE ALGINIC ACID SALT MEMBRANE INSERTED IN VIVO

Twelve kinds of alginic acid salt membrane originally produced by our laboratory, were basically studied inserting into the muscle of rabbits in order to determine their absorbability. According to the over-all results of my experiments, the pyogenic reaction or the disturbance of the general function of rabbit caused by the salt membrane was not evident. The salt membrane causes reaction normally observed in the course of formation of granulation tissue and it is almost organized in 4 weeks. There was no essential difference evident in the absorptive mechanism of the membrane. It was further observed that the rate of absorption and the irritability of the membrane depend upon the kind and the amount of the salt employed. Though the inorganic foreign materials are now being utilized as inserting materials in surgery, it is interesting to note that the alginic acid is capable of controlling the mechanism and the rate of absorption not only physicochemically but also biologically by the various salts. It is my belief that by improvement of these salt membranes it is possible to employ them in various clinical conditions as soft, absorbable materials in surgery. (author's abstract)

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