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[PDF: Members Only] J.Jpn. Surg. Soc.. 123(1): 12-17, 2022
Feature topic
DEVELOPMENT OF IMMUNOREGULATORY STRATEGIES IN CELLULAR AND TISSUE TRANSPLANTATION USING PLURIPOTENT STEM CELLS AND APPLICATIONS IN TRANSPLANT MEDICINE
Human pluripotent stem cells including embryonic stem cells and induced pluripotent stem cells provide great opportunities for cell therapies against intractable diseases such as organ failure. When pluripotent stem cells are derived from allogeneic donors who are genetically and immunologically different from recipients, their immunogenicity could induce a fundamental problem. We have investigated and developed optimized immunoregulatory strategies for transplantation using allogeneic pluripotent stem cells, and the research may resolve the immunological problems. However, two major challenges in this research and clinical field remain, which are expected to be resolved by next-generation surgeon-scientists. One is the improvement of the results of pluripotent stem cell-based transplantation to levels comparable to those of organ transplantation. The other is to develop novel concepts and techniques to regenerate or restore injured tissue or organs without relying solely on transplantation techniques.
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